Stimulation of Cellular DNA Synthesis by Human Cytomegalovirus
AUTOR(ES)
Jeor, Stephen C. St.
RESUMO
Human cytomegalovirus (CMV) is able to induce cellular DNA synthesis in both permissive (human embryonic lung) and nonpermissive (Vero) cells. The induction of cell DNA synthesis was assayed by the incorporation of [methyl-3H]thymidine into macromolecules having the buoyant density characteristics of cell DNA. The DNA synthesis induced by CMV infection appears to represent normal semiconservative replication as opposed to repair synthesis. Both strains of CMV tested were capable of inducing cell DNA synthesis. Virus exposed to heat or UV light prior to infection lost the ability to induce DNA synthesis, indicating that a virus-coded function expressed after infection is responsible for stimulation of cell DNA synthesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=355304Documentos Relacionados
- Stimulation of Cellular Thymidine Kinases by Human Cytomegalovirus
- Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA
- The human cytomegalovirus immediate early 2 protein dissociates cellular DNA synthesis from cyclin-dependent kinase activation
- Induction of cellular hsp70 expression by human cytomegalovirus.
- Replication of human cytomegalovirus DNA: lack of dependence on cell DNA synthesis.