Stimulation of the Hexose Monophosphate Shunt in Human Neutrophils by Ascorbic Acid: Mechanism of Action
AUTOR(ES)
DeChatelet, Lawrence R.
RESUMO
The addition of either ascorbic acid or dehydroascorbic acid to a suspension of polymorphonuclear leukocytes caused a dramatic increase in the resting hexose monophosphate shunt activity. A sequence of reactions involving dehydroascorbate, reduced glutathione, and reduced nicotinamide adenine dinucleotide phosphate is described to explain this stimulation. This sequence could provide an alternate method of producing H2O2 and a bactericidal mechanism which is independent of myeloperoxidase.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=444158Documentos Relacionados
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