Structural analysis of repetitive DNA sequences in the bovine corticotropin-beta-lipotropin precursor gene region.
AUTOR(ES)
Watanabe, Y
RESUMO
Repetitive DNA sequences in the bovine corticotropin-beta-lipotropin precursor gene region have been mapped and subjected to nucleotide sequence analysis. Two of the four repetitive DNA segments found are located in the 5'-flanking region, and one each within the intervening sequences. Each repetitive DNA segment contains one to three highly homologous unit sequences with an approximate length of 120 base pairs. All the unit sequences are flanked on the 3' side by tandem repeats. There are about 10(5) copies of the repetitive DNA in the bovine genome. Comparison of the bovine repetitive sequences with those of other mammalian species reveals the presence of a homologous segment of approximately 40 base pairs. This segment and the region preceding it in the bovine repetitive DNA exhibit sequence homology with the region encompassing the origin of DNA replication in papovaviruses.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=320542Documentos Relacionados
- DNA sequences required for transcription in vivo of the human corticotropin-beta-lipotropin precursor gene.
- Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene.
- Construction of bacterial plasmids that contain the nucleotide sequence for bovine corticotropin-beta-lipotropin precursor.
- Repetitive DNA sequences in the human corticotropin-beta-lipotrophin precursor gene region: Alu family members.
- Processing of the precursor to corticotropin and beta-lipotropin in humans.
