Structural Proteins of Simian Virus 40: Phosphoproteins

AUTOR(ES)

Tan, K. B.

RESUMO

All five structural polypeptides of infectious simian virus 40 grown in African green monkey kidney cells were found to be phosphorylated. The polypeptides with the largest and smallest molecular weights are phosphorylated to a somewhat lower extent than the other polypeptides. The protein moiety of “empty” virus, which is essentially devoid of deoxyribonucleic acid, exhibited a degree of phosphorylation similar to that of infectious virus. In the major polypeptide (molecular weight: 49,000), the phosphate appears to be bound to the seryl or threonyl residues, or both. The nature of the phosphate-polypeptide bond in the other viral polypeptides remains obscure.

Documentos Relacionados

• Structural Proteins of Simian Virus 40
• Minichromosome of simian virus 40: presence of histone HI.
• Cell Killing by Simian Virus 40: Protective Effect of Chloroquine
• Temperature-Sensitive Mutants of Simian Virus 40: Infection of Permissive Cells
• Plaque Formation with Simian Virus 40: Enhancement by Dimethyl Sulfoxide