Structural variation of the pseudoautosomal region between and within inbred mouse strains.

AUTOR(ES)

Kipling, D

RESUMO

The pseudoautosomal region (PAR) is a segment of shared homology between the sex chromosomes. Here we report additional probes for this region of the mouse genome. Genetic and fluorescence in situ hybridization analyses indicate that one probe, PAR-4, hybridizes to the pseudoautosomal telomere and a minor locus at the telomere of chromosome 9 and that a PCR assay based on the PAR-4 sequence amplifies only the pseudoautosomal locus (DXYHgu1). The region detected by PAR-4 is structurally unstable; it shows polymorphism both between mouse strains and between animals of the same inbred strain, which implies an unusually high mutation rate. Variation occurs in the region adjacent to a (TTAGGG)n array. Two pseudoautosomal probes can also hybridize to the distal telomeres of chromosomes 9 and 13, and all three telomeres contain DXYMov15. The similarity between these telomeres may reflect ancestral telomere-telomere exchange.

Documentos Relacionados

• Gene expression variation between mouse inbred strains
• Genetic Variation in Coding Regions Between and Within Commonly Used Inbred Rat Strains
• Intrauterine transmission of Sendai virus in inbred mouse strains.
• Susceptibility and resistance to poliovirus-induced paralysis of inbred mouse strains.
• Comparative molecular genetic analysis of lymphomas from six inbred mouse strains.