Structure of an Escherichia coli N-acetyl-d-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 Å resolution

AUTOR(ES)

Campeotto, Ivan

FONTE

International Union of Crystallography

RESUMO

The 1.45 Å structure of E. coli N-acetyl-d-neuraminic acid lyase in complex with pyruvate in space group P212121 is reported from new low-salt crystallization conditions that will facilitate soaking experiments with substrates and inhibitors.

Documentos Relacionados

• Regulation of sialic acid metabolism in Escherichia coli: role of N-acylneuraminate pyruvate-lyase.
• N-acetyl-heparosan lyase of Escherichia coli K5: gene cloning and expression.
• Role of Pyruvate and S-Adenosylmethionine in Activating the Pyruvate Formate-Lyase of Escherichia coli1
• The molecular structure of a 4'-epiadriamycin complex with d(TGATCA) at 1.7A resolution: comparison with the structure of 4'-epiadriamycin d(TGTACA) and d(CGATCG) complexes.
• Molecular Structure of the Pyruvate Dehydrogenase Complex from Escherichia coli K-12