Structure of replicating herpes simplex virus DNA.
AUTOR(ES)
Jongeneel, C V
RESUMO
We have investigated the molecular anatomy of the herpes simplex virus replicative intermediates by cleavage with the restriction endonuclease BglII. We find that in populations of multiply infected cells, pulse-labeled replicating herpes simplex virus DNA contains at least two and probably all four sequence isomers. Also, it contains no detectable termini. In pulse-chase experiments, we show that endless replicative intermediates are the precursors to virion DNA and that maturation is a relatively slow process. The results are discussed in terms of their significance to possible models of herpes simplex virus DNA replication.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=171377Documentos Relacionados
- Anatomy of Herpes Simplex Virus DNA. VIII. Properties of the Replicating DNA
- Herpes simplex virus induces the replication of foreign DNA.
- Anatomy of herpes simplex virus DNA. V. Terminally repetitive sequences.
- Unstable heterozygosity in a diploid region of herpes simplex virus DNA.
- Electron microscopic mapping of proteins bound to herpes simplex virus DNA.