Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme

AUTOR(ES)

Elling, Robert A.

FONTE

International Union of Crystallography

RESUMO

A crystal structure of zebrafish Plk1 reveals the binding of an extended ATP-competitive inhibitor that targets the adaptive pocket and helps to order the activation segment of the kinase. The conformation of the segment resembles that observed in a nonphosphorylated ligand-free wild-type kinase domain.

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