Studies of rabbit testes infected with Treponema pallidum. III. Immunosuppressive activity of infiltrating mononuclear cells.

AUTOR(ES)

Wicher, V

RESUMO

When mononuclear cells infiltrating rabbit testes infected with Treponema pallidum were cocultured with autologous or homologous peripheral blood lymphocytes spontaneous stimulation and that induced by concanavalin A were suppressed. The inhibition was not due to the cytotoxic effect of the mononuclear cells or to their interference with the active site of concanavalin A (competitive inhibition). The suppressor activity was present in both T and non-T cells but was not affected by pretreatment of the mononuclear cells with indomethacin, a prostaglandin synthetase inhibitor. The suppressor activity may be intrinsic to the mononuclear cells or acquired by the cells in the testicular environment.

Documentos Relacionados

• Studies of rabbit testes infected with Treponema pallidum. I Immunopathology.
• Studies of rabbit testes infected with Treponema pallidum. II Local synthesis of antibodies.
• Antimicrobial activity of rabbit leukocyte defensins against Treponema pallidum subsp. pallidum.
• Secondary lesions in rabbits experimentally infected with Treponema pallidum.
• Mucopolysaccharides in suspensions of Treponema pallidum extracted from infected rabbit testes.