Studies of the Mechanism of Anthranilate Synthase Reaction*
AUTOR(ES)
Tamir, H.
RESUMO
The enzyme anthranilate synthase catalyzes the formation of anthranilate form either chorismate and glutamine or chorismate and ammonia. In the aromatization of chorismate, a hydroxyl group and an enolpyruvyl group must be eliminated. Elimination of the enolpyruvyl group of chorismate is accompanied by protonation to form pyruvate. The source of this proton was investigated by performing the enzymatic reaction in 99.7 per cent D2O.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283079Documentos Relacionados
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