Studies on the disturbance of glucuronide formation in infectious hepatitis
AUTOR(ES)
Vest, M. F.
RESUMO
The ability of the liver to form glucuronides was measured in 10 patients with infectious hepatitis. One test was done at the onset and another about four weeks later after the clinical symptoms had disappeared. N-acetyl-p-aminophenol (N.A.P.A.) or acetanilide was administered in doses ranging from 10 to 20 mg. per kg. body weight, either orally or by intravenous injection. N.A.P.A. is conjugated by the liver at the hydroxyl group and excreted in the urine as sulphuric and glucuronic acid conjugates. Total conjugated p-aminophenol, free N.A.P.A., and N.A.P.A. glucuronide were estimated in the urine of our patients. In the blood the disappearance of N.A.P.A. (free form) and the formation of N.A.P.A. glucuronide were traced.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=480267Documentos Relacionados
- STUDIES ON THE RELATIONSHIP OF THE HEPATITIS VIRUS TO PERSISTENT SYMPTOMS, DISABILITY, AND HEPATIC DISTURBANCE (“CHRONIC HEPATITIS SYNDROME”) FOLLOWING ACUTE INFECTIOUS HEPATITIS 1
- STUDIES ON THE NEONATAL DEVELOPMENT OF THE GLUCURONIDE CONJUGATING 12
- Epidemiologic Studies of a Large Urban Outbreak of Infectious Hepatitis
- STUDIES OF COPROPORPHYRIN. IV. THE PER DIEM EXCRETION AND ISOMER DISTRIBUTION IN THE URINE IN INFECTIOUS HEPATITIS, INFECTIOUS MONONUCLEOSIS, AND MECHANICAL JAUNDICE 1
- Studies on Phenolic Steroids in Human Subjects. VII. Metabolic Fate of Estriol and Its Glucuronide*