Study of the immunologic molecular profile in operational tolerance kidney transplanted individuals / Estudo do perfil imunológico molecular em indivíduos transplantados renais com tolerância operacional

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

standard immunosuppression, lead us to suggest that these cells may be affected by immunosuppression. Moreover, the higher numbers of CD4+CD25+Foxp3+ T cells observed in TO and BI individuals suggest that these cells may have an important role in the induction/maintenance of these two homeostatic states of minimal, or of no aggression to the graft. Furthermore, the higher mRNA expression of GATA-3, in the TO group, suggests that a Th2 deviation may also be relevant to the maintenance of operational tolerance. Our results allowed us to interpret that the state of operational tolerance has systemic repercussion, and that the molecules studied in our work may be relevant to the process of homeostasis in the context of human kidney transplantation.

ASSUNTO(S)

sinalização intracelular transplante foxp3 intracellular signaling tolerância operacional células t reguladoras foxp3 kidney transplantation operational tolerance regulatory t cells

ACESSO AO ARTIGO

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