Sulfhydryl Compounds in Melanocytes of Yellow (Ay/a ), Nonagouti (a/a), and Agouti (A/A) Mice

AUTOR(ES)

Galbraith, Donald B.

RESUMO

Cleffmann (1953, 1963a,b) has reported that yellow but not black melanocytes of agouti (A/A) rabbits contained reducing sulfhydryl compounds. We have attempted to repeat Cleffmann's observations in mouse melanocytes of the lethal yellow (Ay/a), nonagouti (a/a) and agouti (A/A) genotypes. Our results contradict those of Cleffmann and reveal that yellow and black melanocytes, regardless of genotype, possess equivalent amounts of histochemically detectable sulfhydryl compounds. These results do not support the hypothesis that agouti-locus genes act by controlling the sulfhydryl metabolism of pigment cells.

Documentos Relacionados

• Growth of Inbred Yellow (AYa) and Non-Yellow (aa) Mice in Parabiosis
• Influence of Background Genome on Enzymatic Characteristics of Yellow (Ay/-, Avy/-) Mice
• Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice.
• Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.
• An agouti mutation lacking the basic domain induces yellow pigmentation but not obesity in transgenic mice