Suppression of Human Growth Hormone Secretion by Melatonin and Cyproheptadine
AUTOR(ES)
Smythe, G. A.
RESUMO
Pituitary growth hormone (GH) release in the rat is stimulated via serotoninergic pathways and can be inhibited by treatment with compounds that act as serotonin antagonists, such as cyproheptadine or the pineal gland hormone, melatonin. To investigate a possible role for serotonin in the control of human GH release, the effects of cyproheptadine and melatonin administration on the GH responses of normal male subjects were examined.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=301530Documentos Relacionados
- Suppression by cyproheptadine of human growth hormone and cortisol secretion during sleep.
- Suppression of sleep-related prolactin secretion and enhancement of sleep-related growth hormone secretion.
- Direct effects of thyrotropin-releasing hormone, cyproheptadine, and dopamine on adrenocorticotropin secretion from human corticotroph adenoma cells in vitro.
- Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin.
- Targeted disruption of a human interferon-inducible gene detected by secretion of human growth hormone.