Susceptibility of Anaerobic Bacteria to Ten Antimicrobial Agents
AUTOR(ES)
Appelbaum, Peter C.
RESUMO
The susceptibility pattern of 265 anaerobic bacteria from clinical isolates to 10 antimicrobial agents was investigated by the agar dilution technique. Penicillin G, in a concentration of 16 μg/ml, was active against most organisms, important exceptions being 12% of Bacteroides melaninogenicus and 24% of B. fragilis strains. The susceptibility of strains to ampicillin was similar to their susceptibility to penicillin G. Carbenicillin, at ≤128 μg/ml, inhibited all but a few strains. Cefamandole was less active than the penicillins; 82% of B. melaninogenicus, 32% of B. fragilis, and 75% of Fusobacterium strains were inhibited by ≤16 μg/ml. A trend towards tetracycline resistance was seen in many bacterial groups, especially Bacteroides, Fusobacterium, and Clostridium. All organisms were susceptible to chloramphenicol and clindamycin in concentrations of ≤16 μg/ml and ≤4 μg/ml, respectively. Erythromycin was less active than clindamycin against all strains tested. Metronidazole and tinidazole were active against most anaerobes, but resistance of a few strains in each group was encountered. The increased resistance of B. melaninogenicus strains to penicillin, and emergence of anaerobes resistant to >16 μg of imidazole per ml may have therapeutic implications.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352467Documentos Relacionados
- Susceptibility of Anaerobic Bacteria to 23 Antimicrobial Agents
- Comparative Susceptibility of Anaerobic Bacteria to Ticarcillin, Cefoxitin, Metronidazole, and Related Antimicrobial Agents
- Susceptibility of anaerobic bacteria to nine antimicrobial agents and demonstration of decreased susceptibility of Clostridium perfringens to penicillin.
- In vivo susceptibility of the Legionnaires disease bacterium to ten antimicrobial agents.
- Standardized Antimicrobial Disc Susceptibility Testing of Anaerobic Bacteria. I. Susceptibility of Bacteroides fragilis to Tetracycline