Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities

AUTOR(ES)

Gomes, Sara L. S., Militão, Gardenia C. G., Costa, Arinice M., Pessoa, Cláudia Ó., Costa-Lotufo, Letícia V., Cunha-Junior, Edézio F., Torres-Santos, Eduardo C., Costa, Paulo R. R., Silva, Alcides J. M. da

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2017-08

RESUMO

A series of 2-hydroxy-3-arylnaphthalene-1,4-diones (3-aryllawsones) were synthesized by Suzuki-Miyaura cross coupling reaction of 3-iodolawsone with arylboronic acids/esters. The hydroxylated resulting products were transformed into their corresponding N,N-diethyl carbamates. The antineoplastic and antileishmanial activities of the compounds were evaluated and compared with lapachol and its carbamate, providing promising results.

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