Synergistic effect of human leukocyte interferon and nonoxynol 9 against herpes simplex virus type 2.
AUTOR(ES)
Rapp, F
RESUMO
The nonionic surfactant nonoxynol 9 (NP9), in combination with human alpha interferon, synergistically reduced the titer of herpes simplex virus type 2 (HSV-2) in vitro. The degree of synergy was highest at an interferon concentration of 10(3) IU/ml and an NP9 dilution of 1:1,500. We postulate that NP9 inactivates extracellular HSV-2, whereas interferon inhibits HSV-2 replication at the intracellular level.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=180273Documentos Relacionados
- Induction of human cell DNA synthesis by herpes simplex virus type 2.
- Synergistic Effect of Herpes Simplex Virus and Cytosine Arabinoside on Human Chromosomes
- Urticarial manifestations associated with herpes simplex virus type 2.
- Effect of actinomycin D on the expression of herpes simplex virus-common surface antigen in cells transformed by herpes simplex virus type 2.
- Synergistic activity of combinations of recombinant human alpha interferon and acyclovir, administered concomitantly and in sequence, against a lethal herpes simplex virus type 1 infection in mice.