Synergistic interaction of trimethoprim and sulfamethoxazole on Paracoccidioides brasiliensis.
AUTOR(ES)
Stevens, D A
RESUMO
The in vitro interaction of trimethoprim and sulfamethoxazole on clinical isolates of Paracoccidioides brasiliensis was studied. With complete inhibition and a visual endpoint used as the criteria, three of four strains had minimal inhibitory concentrations that indicated resistance to sulfamethoxazole, and all four strains were resistant to trimethoprim. A marked synergism in inhibition was noted with the combination of these drugs against sulfa-resistant strains. A sulfamethoxazole/trimethoprim ratio of 5:1 was the most synergistic. Fifty percent inhibition, determined spectrophotometrically, of the strains could be achieved with sulfamethoxazole alone. In summary, the striking synergy observed suggests that combination chemotherapy with these drugs deserves further study.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=182028Documentos Relacionados
- Molecular detection and identification of Paracoccidioides brasiliensis.
- Caracterização de marcadores de virulência em Paracoccidioides brasiliensis.
- Effect of detergents on membrane-associated glucan synthetase from Paracoccidioides brasiliensis.
- Estudos sobre o envolvimento de membrane rafts e a ativação de quinases de células epiteliais durante a interação com Paracoccidioides brasiliensis.
- Estudo de proteinases e citocinas na resposta granulomatosa em camundongos infectados com Paracoccidioides brasiliensis.