Synthesis and Characterization of a Protective Peptide-Based Vaccine against Schistosoma mansoni

AUTOR(ES)

Tarrab-Hazdai, Rebeca

FONTE

American Society for Microbiology

RESUMO

Two synthetic peptides, corresponding to the N-terminal sequence of the 45-kDa subunit of the protective 9B antigen of Schistosoma mansoni and differing in only one amino acid residue, were synthesized. These peptides were recognized by the protective monoclonal antibody 152-66-9B, as well as by sera of mice and humans infected with schistosomiasis. The peptides were coupled to a protein carrier and used for immunization. One of the peptides, 9B-peptide1, induced in mice significant protection against challenge infection, manifested in a 40 to 50% reduction in worm burden.

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