Synthesis of nucleic acid methylphosphonothioates.
AUTOR(ES)
Roelen, H C
RESUMO
The reagent obtained in situ by treating methylphosphonothioic dichloride with 1-hydroxy-6-trifluoromethylbenzotriazole could be used for the introduction of methylphosphonothioate linkages. The individual diastereomers of the protected dimer d-Tp(S,Me)A were applied in the synthesis of the chiral pure (R or S) hexamers d-[CpCpTp(S,Me)ApGpG]. The reagent showed also to be very effective for the preparation of the 3',5'-cyclic methylphosphonothioate of uridine.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=338431Documentos Relacionados
- NUCLEIC ACID PRECURSORS AND PROTEIN SYNTHESIS
- NUCLEIC ACID SYNTHESIS IN ULTRAVIOLET-IRRADIATED BACILLUS CEREUS
- Pyrophosphate-condensing activity linked to nucleic acid synthesis.
- THE SYNTHESIS OF NUCLEIC ACID BY VIRUS-INFECTED BACTERIA 1
- DIRECT EVIDENCE FOR NUCLEAR SYNTHESIS OF CYTOPLASMIC RIBOSE NUCLEIC ACID
