T-cell proliferative response to hapten-modified self-immunoglobulins: recognition of conjugate-specific determinants.
AUTOR(ES)
Bikoff, E
RESUMO
(4-Hydroxy-3-nitrophenyl)acetyl (NP)-modified BALB/c immunoglobulins were used as the immunogen for induction of a proliferative response in BALB/c mice. As is true for responses to other soluble antigens, proliferation was dependent on Lyt-1 cells and histocompatible radioresistant accessory cells. Lyt-1 cells directed against NP-modified self immunoglobulin are specific for the immunizing hapten NP. However, they do not recognize hapten per se. Rather, they see complex determinants comprised of both the hapten NP and the immunoglobulin self-carrier. Distinct specificities were created by coupling the same hapten to different monoclonal BALB/c antibody molecules or by attaching the hapten to the immunoglobulin self-carrier via a spacer molecule. It is proposed that determinants created by attaching haptens to self-immunoglobulin molecules are similar to those recognized by anti-idiotypic T cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=346596Documentos Relacionados
- Recognition of Hapten-Modified Cells In Vitro by Human T Lymphocytes
- Clonal expansion of T lymphocytes in human melanoma metastases after treatment with a hapten-modified autologous tumor vaccine.
- T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis.
- Proliferation and differentiation of single hapten-specific B lymphocytes is promoted by T-cell factor(s) distinct from T-cell growth factor.
- T-cell proliferative response to human papillomavirus type 16 peptides: relationship to cervical intraepithelial neoplasia.