Targeted expression of a human pituitary tumor–derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis
AUTOR(ES)
Ezzat, Shereen
FONTE
American Society for Clinical Investigation
RESUMO
It is estimated that up to one in five individuals develop pituitary gland tumors. Despite the common occurrence of these tumors, the pathogenetic mechanisms underlying their development remain largely unknown. We report the identification of a novel pituitary tumor–derived, N-terminally truncated isoform of FGF receptor-4 (ptd-FGFR4). The corresponding mRNA results from alternative transcription initiation and encodes a polypeptide that lacks a signal peptide and the first two extracellular Ig-like domains. ptd-FGFR4 has a distinctive cytoplasmic residence, is constitutively phosphorylated, and is transforming in vitro and in vivo. Here we show that targeted expression of ptd-FGFR4, but not FGFR4, results in pituitary tumors that morphologically recapitulate the human disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=150823Documentos Relacionados
- Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent
- Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB
- Isolation and primary structure of tumor-derived peptides related to human pancreastatin and chromogranin A.
- Human tumor-derived genomic DNA transduced into a recipient cell induces tumor-specific immune responses ex vivo
- Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.