Tetanus Toxin and Antigenic Derivatives II. Effect of Protein and Formaldehyde Concentration on Toxoid Formation

AUTOR(ES)

Murphy, Samuel G.

RESUMO

Tetanus toxoid formation was examined under varying conditions. Products of the reaction depended upon the concentration of both formaldehyde and toxin. High concentrations of protein and formaldehyde favored the formation of large polymers, whereas low concentrations yielded smaller polymers and monomer. The monomer had an observed S value of 7.1, whereas the polymers ranged from 10.1S to 110S. The cross-linking between toxin molecules to form toxoid polymers appeared to be random.

Documentos Relacionados

• Development of a Purified Cholera Toxoid II. Preparation of a Stable, Antigenic Toxoid by Reaction of Purified Toxin with Glutaraldehyde
• Tetanus Toxin and Antigenic Derivatives I. Purification of the Biologically Active Monomer
• The Purification and Concentration of Diphtheria Toxin: II. Observations on the Nature of the Toxin
• CONVERSION OF HYDROLYSATE TETANUS TOXIN TO TOXOID 1
• PLASMAPHERESIS EDEMA. II. THE EFFECT OF REDUCTION OF SERUM PROTEIN ON THE ELECTROLYTE PATTERN AND CALCIUM CONCENTRATION