The capsular polysaccharide of Enterococcus faecalis and its relationship to other polysaccharides in the cell wall
AUTOR(ES)
Hancock, Lynn E.
FONTE
The National Academy of Sciences
RESUMO
With the goal of identifying and characterizing traits of Enterococcus faecalis that play key roles in human disease, we identified an operon specifying synthesis of a capsular carbohydrate of the type most commonly expressed by clinical isolates. This surface-exposed carbohydrate consists of glycerol phosphate, glucose, and galactose residues, and its biosynthesis is encoded by a determinant that includes 11 ORFs. Insertional inactivation of genes in this pathway yielded mutants with enhanced susceptibility to phagocytic killing in vitro and compromised in the ability to persist in regional lymph nodes in vivo.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=122232Documentos Relacionados
- Serological and Genetic Diversity of Capsular Polysaccharides in Enterococcus faecalis
- Enterococcus faecalis Capsular Polysaccharide Serotypes C and D and Their Contributions to Host Innate Immune Evasion▿
- Isolation and Chemical Characterization of a Capsular Polysaccharide Antigen Shared by Clinical Isolates of Enterococcus faecalis and Vancomycin-Resistant Enterococcus faecium
- Autolytic Enzyme System of Streptococcus faecalis V. Nature of the Autolysin-Cell Wall Complex and Its Relationship to Properties of the Autolytic Enzyme of Streptococcus faecalis
- Cell Wall Chemical Composition of Enterococcus faecalis in the Viable but Nonculturable State