The case of sulfonation in the chemical synthesis of oligonucleotides.
AUTOR(ES)
Kraszewski, A
RESUMO
The sulfonation of nucleosidic component, a side reaction during phosphotriester bond formation, as a function of the reactivity of the condensing agents and the kind of substituents in the starting phosphodiester is discussed. It was found that in the coupling reaction of nucleoside alkyl phosphodiesters, the degree of sulfonation of the nucleosidic component was very high; while under the same conditions when the aryl group was present in the corresponding phosphodiester, this side reaction practically did not occur.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=324079Documentos Relacionados
- Syringe method for stepwise chemical synthesis of oligonucleotides.
- Enzymatic synthesis of RNA oligonucleotides.
- Synthesis and application of derivatizable oligonucleotides.
- Synthesis and hybridization properties of inverse oligonucleotides.
- Synthesis and hybridization of a series of biotinylated oligonucleotides.
