The Common Ovine Shiga Toxin 2-Containing Escherichia coli Serotypes and Human Isolates of the Same Serotypes Possess a Stx2d Toxin Type
AUTOR(ES)
Ramachandran, Vidiya
FONTE
American Society for Microbiology
RESUMO
Shiga toxin 2 (Stx2) has been reported as the main Shiga toxin associated with human disease. In addition, the Stx2 toxin type can have a profound impact on the degree of tissue damage in animal models. We have characterized the stx2 subtype of 168 Shiga toxin-producing Escherichia coli (STEC) isolates of which 146 were derived from ovine sources (principally feces and meat) and 22 were isolated from humans. The ovine STEC isolates were of serotypes that have been shown to occur commonly in the gastrointestinal tract of healthy sheep. The major stx2 subtype in the ovine isolates was shown to be stx2d-Ount (119 of 146 [81.5%]) and was predominantly associated with serotypes O75:H−/H8/H40, O91:H−, O123:H−, O128:H2, and OR:H2. However, 17 of 18 (94.4%) ovine isolates of serotype O5:H− possessed a stx2d-O111/OX3a subtype. Furthermore, STEC isolates of serotypes commonly found in sheep and recovered from both clinical and nonclinical human infections also contained a stx2d (stx2d-Ount/O111/OX3a) subtype. These studies suggest that a specific stx2 subtype(s) associates with serotype and may have important epidemiological implications for tracing sources of E. coli during outbreaks of STEC-associated diseases in humans.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=88051Documentos Relacionados
- Bovine Non-O157 Shiga Toxin 2-Containing Escherichia coli Isolates Commonly Possess stx2-EDL933 and/or stx2vhb Subtypes
- stx1c Is the Most Common Shiga Toxin 1 Subtype among Shiga Toxin-Producing Escherichia coli Isolates from Sheep but Not among Isolates from Cattle
- Presence of Activatable Shiga Toxin Genotype (stx2d) in Shiga Toxigenic Escherichia coli from Livestock Sources
- Clinical Isolates of Non-O157 Shiga Toxin-Producing Escherichia coli: Serotypes, Virulence Characteristics, and Molecular Profiles of Strains of the Same Serotype
- A New Shiga Toxin 2 Variant (Stx2f) from Escherichia coli Isolated from Pigeons