The complement control protein homolog of herpesvirus saimiri regulates serum complement by inhibiting C3 convertase activity.
AUTOR(ES)
Fodor, W L
RESUMO
The herpesvirus saimiri genome encodes a complement control protein homolog (CCPH). Stable mammalian cell transfectants expressing a recombinant transmembrane form of CCPH (mCCPH) or a 5'FLAG epitope-tagged mCCPH (5'FLAGmCCPH) conferred resistance to complement-mediated cell damage by inhibiting the lytic activity of human serum complement. The function of CCPH was further defined by showing that the mCCPH and the 5'FLAGmCCPH transfectants inhibited C3 convertase activity and effectively reduced cell surface deposition of the activated complement component, C3d.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=189111Documentos Relacionados
- Inhibition of the alternative C3 convertase and classical C5 convertase of complement by group A streptococcal M protein.
- Regulation of the activity of platelet-bound C3 convertase of the alternative pathway of complement by platelet factor H.
- Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane
- Complement C3 convertase: Cell surface restriction of β1H control and generation of restriction on neuraminidase-treated cells
- Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator.