The Consequences of Nullosomy for a Chromosomal Region Affecting Cyclic Amp Phosphodiesterase Activity in Drosophila
AUTOR(ES)
Kiger, John A.
RESUMO
A study of Drosophila nullosomic for chromomere 3D4 shows that this region of the genome is necessary for male fertility, normal female fertility and normal oogenesis. Males nullosomic for 3D4 lack normal, motile sperm. Females nullosomic for this region exert a maternal influence on their progeny which results in a diversity of imaginal defects. The observation that chromomere 3D4 is the most probable locus for a chromosomal region which affects cAMP phosphodiesterase activity, and which may contain a structural gene for the enzyme, prompts the hypothesis that the diverse physiological effects caused by nullosomy for 3D4 are the result of an aberrant cAMP metabolism.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1213645Documentos Relacionados
- Cyclic AMP phosphodiesterase in Thermomonospora curvata.
- Cyclic AMP-Mediated Induction of the Cyclic AMP Phosphodiesterase of C-6 Glioma Cells
- A Genetically Distinct Form of Cyclic Amp Phosphodiesterase Associated with Chromomere 3d4 in DROSOPHILA MELANOGASTER
- Induction of cyclic AMP phosphodiesterase in Blastocladiella emersonii and its relation to cyclic AMP metabolism.
- A Cytogenetic Analysis of Cyclic Nucleotide Phosphodiesterase Activities in Drosophila
