The Crystal and Molecular Structure of an Intermolecular Complex between Riboflavin and an Adenosine Derivative

AUTOR(ES)

Voet, Donald

RESUMO

Riboflavin and the adenosine derivative 5′-bromo-5′-deoxyadenosine form a crystalline 1:1 intermolecular complex, the structure of which has been solved by x-ray diffraction analysis. The adenine ring is found to be joined by two hydrogen bonds to the uracillike end of the riboflavin isoalloxazine ring. In addition, the riboflavin and the adenosine molecules associate through the formation of stacks of alternating parallel adenine and isoalloxazine rings. These intermolecular associations are considered to be models for intramolecular association in the coenzyme flavin adenine dinucleotide (FAD), which contains both adenosine and riboflavin.

Documentos Relacionados

• THE CRYSTAL STRUCTURE OF AN INTERMOLECULAR NUCLEOSIDE COMPLEX: ADENOSINE AND 5-BROMOURIDINE*
• THE CRYSTAL STRUCTURE OF AN INTERMOLECULAR COMPLEX CONTAINING A GUANINE AND A CYTOSINE DERIVATIVE*
• Crystal structure of pyrogallol–phloroglucinol transhydroxylase, an Mo enzyme capable of intermolecular hydroxyl transfer between phenols
• Crystal structure of the complex between thrombin and the central “E” region of fibrin
• The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches.