The Effect of mei-41 on Rdna Redundancy in DROSOPHILA MELANOGASTER
AUTOR(ES)
Hawley, R. Scott
RESUMO
The recombination and repair defective mutant, mei-41, exhibits three rather striking effects on the genetic properties and chromosomal stability of rDNA in Drosophila. First, mei-41 inhibits rDNA magnification. However, mei-9, another recombination and repair defective mutation has no similar effect. This indicates that magnification requires some, but not all, of the gene products necessary for meiotic exchange. Second, under magnifying conditions, mei-41 induces interchanges between the X rDNA and either arm of the Ybb- chromosome. These interchanges occur at high frequency and are independent of rDNA orientation. Third, in mei-41 bb+/Ybb+ males, bobbed mutants in the X, but not the Y, also arise at high frequency. Evidence suggests that these events involve the rDNA type I insertion. The recombination and repair defective properties of mei-41 together with our results regarding its unusual and specific effects involving rDNA are explained in a simple model that has general implications for chromosome structure.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1202069Documentos Relacionados
- Duplicated rDNA sequences of variable lengths flanking the short type I insertions in the rDNA of Drosophila melanogaster.
- Transient expression of Drosophila melanogaster rDNA promoter into cultured Drosophila cells.
- Differential elimination of rDNA genes in bobbed mutants of Drosophila melanogaster.
- Multiple Pol I initiation sequences in rDNA spacers of Drosophila melanogaster.
- Nucleotide sequences at the boundaries between gene and insertion regions in the rDNA of Drosophila melanogaster