The Effects of Colestipol Resin and of Colestipol Plus Clofibrate on the Turnover of Plasma Cholesterol in Man
AUTOR(ES)
Goodman, DeWitt S.
RESUMO
Studies were conducted to determine the effects of colestipol hydrochloride, a new bile acid-sequestrant resin, on some of the parameters of cholesterol turnover and metabolism in man. Three normal volunteers and eight hyperlipidemic patients participated in three sets of cholesterol turnover studies carried out at intervals of approximately 1 yr. The effects of colestipol were assessed by comparing the results obtained before therapy with those obtained on repeat study after several months of resin therapy. Colestipol treatment significantly reduced the serum cholesterol concentration (mean reduction 21%), and produced a large increase in the production rate of cholesterol (mean 86%) and in the turnover rate of cholesterol in pool 1 (mean 46%). The values of the intercompartmental rate constants and of the size of the rapidly exchangeable pool were unchanged with therapy.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=302525Documentos Relacionados
- Turnover of plasma cholesterol in man
- THE EFFECTS OF SQUALENE ON THE INCORPORATION OF ACETATE INTO PLASMA CHOLESTEROL IN MAN 1
- BODY CHOLESTEROL METABOLISM IN MAN. II. MEASUREMENT OF THE BODY CHOLESTEROL MISCIBLE POOL AND TURNOVER RATE*†
- Turnover of individual cholesterol esters in human liver and plasma.
- Estimation of Cholesterol and Bile Acid Turnover in Man by Kinetic Analysis