The EmrR Protein Represses the Escherichia coli emrRAB Multidrug Resistance Operon by Directly Binding to Its Promoter Region
AUTOR(ES)
Xiong, A.
FONTE
American Society for Microbiology
RESUMO
EmrR negatively regulates the transcription of the multidrug resistance pump-encoding operon, emrRAB, by binding to its regulatory region. The binding site spans the promoter and the downstream sequence up to the transcriptional start site of the operon. Structurally unrelated drugs that induce the pump interfere with this binding.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90178Documentos Relacionados
- EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB.
- Purification and Ligand Binding of EmrR, a Regulator of a Multidrug Transporter
- Emr, an Escherichia coli locus for multidrug resistance.
- Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli
- Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB.
