The Entner-Doudoroff Pathway Has Little Effect on Helicobacter pylori Colonization of Mice
AUTOR(ES)
Wanken, Amy E.
FONTE
American Society for Microbiology
RESUMO
Helicobacter pylori mutants deficient in 6-phosphogluconate dehydratase (6PGD) were constructed. Colonization densities were lower and minimum infectious doses were higher for mutant strains than for wild-type strains. In spite of better colonization, however, wild-type strains did not displace the mutant in cocolonization experiments. Loss of 6PGD diminishes the fitness of H. pylori in vivo, but the pathway is nonessential for colonization.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=153294Documentos Relacionados
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