The entry of reovirus into L cells is dependent on vacuolar proton-ATPase activity.
AUTOR(ES)
Martínez, C G
RESUMO
Inhibitors of vacuolar proton-ATPase activity (5 microM bafilomycin A1 or 50 nM concanamycin A) prevented infection by reovirus particles but not by infectious subviral particles (ISVPs). Neither compound affected virus attachment or internalization. However, both compounds potently blocked cleavage of the viral protein mu 1C. Finally, both reovirus particles and ISVPs efficiently translocated the toxin alpha-sarcin to the cytosol during virus entry. Bafilomycin A1 blocked translocation of alpha-sarcin by reovirus particles but not by ISVPs.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=189847Documentos Relacionados
- Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells.
- A plant plasma membrane proton-ATPase gene is regulated by development and environment and shows signs of a translational regulation.
- Requirement for Vacuolar H+-ATPase Activity and Ca2+ Gradient during Entry of Rotavirus into MA104 Cells
- Vaccinia Virus Entry into Cells Is Dependent on a Virion Surface Protein Encoded by the A28L Gene
- Small reovirus-specific particle with polycytidylate-dependent RNA polymerase activity.