The euglobulin lysis time test: An ineffectual monitor of the therapeutic inhibition of fibrinolysis

AUTOR(ES)

Katz, J.

RESUMO

In two clinical situations associated with hyperfibrinolysis the administration of antifibrinolytic drugs resulted in clinical haemostasis. The dilute clot lysis time and fibrin plate activity test but not the euglobulin lysis time reflected this control of excessive fibrinolysis by the antifibrinolytic drugs. The inhibition by epsilon-amino-caproic acid (EACA) of hyperfibrinolysis induced in vitro was reflected by the dilute clot lysis time but not by the euglobulin lysis time. Paper chromatography of the supernatant and euglobulin fractions as prepared for the euglobulin lysis time test from plasma with added EACA demonstrated that some 85% of the EACA was present in the supernatant, normally discarded during the test. Similarly, cellulose-acetate electrophoresis of the supernatant and euglobulin fractions from plasma containing Trasylol demonstrated the drug in the supernatant only. These findings indicate that when acetic acid is added to plasma containing EACA or Trasylol only a small proportion of the drug is precipitated with the euglobulin fraction. The euglobulin lysis time is thus an inaccurate index of the neutralization of hyperfibrinolysis by antifibrinolytic drugs.

Documentos Relacionados

• Automatic determination of euglobulin lysis time
• AN EVALUATION OF THE EUGLOBULIN METHOD FOR THE DETERMINATION OF FIBRINOLYSIS
• A new device for measurement of fibrin clot lysis: application to the Euglobulin Clot Lysis Time
• Serum cholinesterase and euglobulin lysis time in chronic cor pulmonale.
• Methodological study and a recommended technique for determining the euglobulin lysis time