The Gene That Encodes the Herpes Simplex Virus Type 1 Latency-Associated Transcript Influences the Accumulation of Transcripts (Bcl-xL and Bcl-xS) That Encode Apoptotic Regulatory Proteins
AUTOR(ES)
Peng, Weiping
FONTE
American Society for Microbiology
RESUMO
The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-xL transcript versus the Bcl-xS transcript in Neuro-2A cells. Bcl-xL encodes an antiapoptotic protein, whereas Bcl-xS encodes a proapoptotic protein. Promoting the accumulation of Bcl-xL in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=228484Documentos Relacionados
- Herpes simplex virus latency-associated transcript is a stable intron.
- Physical characterization of the herpes simplex virus latency-associated transcript in neurons.
- Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
- The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
- Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival