The Genetic Analysis of a Chromosome-Specific Meiotic Mutant That Permits a Premature Separation of Sister Chromatids in DROSOPHILA MELANOGASTER

AUTOR(ES)

Gethmann, Richard C.

RESUMO

mei-G87 is a recessive meiotic mutant that increases second chromosome nondisjunction in both males and females. A significant proportion of the diplo-2 exceptions are equational. In females, diplo-2 reductional exceptions are usually noncrossovers, but, in equational exceptions, crossover frequency and distribution are the same as that found in the haplo-2 controls. The frequencies of nondisjunction are relatively low: 0.6% in females and 1.3% in males. Nondisjunction frequency is affected by environmental conditions (possibly humidity). The defect in mei-G87, as in other "second division" mutants, appears to be a failure to maintain sister-chromatid cohesion. mei-G87 increases nondisjunction of only the second chromosome. This may indicate either a weak mutant with only the second chromosome being sensitive enough to misbehave or it may indicate that chromosome-specific regions responsible for sister-chromatid cohesion exist.

Documentos Relacionados

• Painting of fourth, a chromosome-specific protein in Drosophila
• The Yeast Med1 Mutant Undergoes Both Meiotic Homolog Nondisjunction and Precocious Separation of Sister Chromatids
• Genomic analysis of human multigene families using chromosome-specific vectorette PCR.
• Integrative selection of human chromosome-specific yeast artificial chromosomes.
• Chromosome-specific recombinant DNA libraries from the fungus Aspergillus nidulans.