The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives
AUTOR(ES)
Pavlović, Davor
FONTE
The National Academy of Sciences
RESUMO
We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=156333Documentos Relacionados
- Subcellular Localization and Topology of the p7 Polypeptide of Hepatitis C Virus
- The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences
- Characterization of Determinants Important for Hepatitis C Virus p7 Function in Morphogenesis by Using trans-Complementation▿
- Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini.
- Candida albicans estrogen-binding protein gene encodes an oxidoreductase that is inhibited by estradiol.