The Heritable Activation of Cryptic Suppressor-Mutator Elements by an Active Element
AUTOR(ES)
Fedoroff, N.
RESUMO
A weakly active maize Suppressor-mutator (Spm-w) element is able to heritably activate cryptic Spm elements in the maize genome. The spontaneous activation frequency, which is 1-5 X 10(-5) in the present genetic background, increases by about 100-fold in the presence of an Spm-w and remains an order of magnitude above the background level a generation after removal of the activating Spm-w. Sectorial somatic reactivation of cryptic elements can be detected phenotypically in kernels. Selection of such kernels constitutes an efficient selection for plants with reactivated Spm elements. Analysis of the reactivation process reveals that it is gradual and proceeds through genetically metastable intermediates that exhibit different patterns of element expression during plant development. Newly reactivated elements tend to return to an inactive form. However, the probability that an element will remain in a heritably active state increases when the element is maintained in the presence of an active Spm element for several generations.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1203643Documentos Relacionados
- Is the Suppressor-Mutator Element Controlled by a Basic Developmental Regulatory Mechanism?
- Mobility of the maize suppressor-mutator element in transgenic tobacco cells.
- Tnpa Trans-Activates Methylated Maize Suppressor-Mutator Transposable Elements in Transgenic Tobacco
- Concerted formation of macromolecular Suppressor–mutator transposition complexes
- RNA splicing permits expression of a maize gene with a defective Suppressor-mutator transposable element insertion in an exon.
