The HTR1 Gene Is a Dominant Negative Mutant Allele of MTH1 and Blocks Snf3- and Rgt2-Dependent Glucose Signaling in Yeast

AUTOR(ES)

Schulte, Frank

FONTE

American Society for Microbiology

RESUMO

Saccharomyces cerevisiae HTR1 mutants are severely impaired in the uptake of glucose. We have cloned dominant HTR1 mutant alleles and show that they encode mutant forms of the Mth1 protein. Mth1 is shown to be involved in carbon source-dependent regulation of its own, invertase and hexose transporter gene expression. The mutant forms block the transduction of the Snf3- and Rgt2-mediated glucose signals upstream of the Rgt1 transcriptional regulator.

Documentos Relacionados

• Grr1-dependent Inactivation of Mth1 Mediates Glucose-induced Dissociation of Rgt1 from HXT Gene Promoters
• Glucose uptake and catabolite repression in dominant HTR1 mutants of Saccharomyces cerevisiae.
• Dominant and Recessive Suppressors That Restore Glucose Transport in a Yeast Snf3 Mutant
• Std1 and Mth1 Proteins Interact with the Glucose Sensors To Control Glucose-Regulated Gene Expression in Saccharomyces cerevisiae
• Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP