The in situ spatial arrangement of the influenza A virus matrix protein M1 assessed by tritium bombardment
AUTOR(ES)
Shishkov, Alexander V.
FONTE
The National Academy of Sciences
RESUMO
Intact influenza A virions were bombarded with thermally activated tritium atoms, and the intramolecular distribution of the label in the matrix protein M1 was analyzed to determine the in situ accessibility of its tryptic fragments. These data were combined with the previously reported x-ray crystal structure of the M1 fragment 2–158 [Sha, B. & Luo, M. (1997) Nat. Struct. Biol. 4, 239–244] and the predicted topology of the C domain (159–252) to propose a model of M1 arrangement in the virus particle.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=22146Documentos Relacionados
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