The Influence of Neighboring Base Pairs upon Base-Pair Substitution Mutation Rates
AUTOR(ES)
Koch, Robert E.
RESUMO
The 2-aminopurine-induced transition, A·T → G·C, was studied at particular sites in bacteriophage T4 as a function of the nearby base-pair composition of the DNA. Changing a base pair changed the transition rate at the adjacent base pair up to 23-fold, and at the next base pair by a lesser amount. Destabilization was achieved by replacing an A·T base pair by a G·C base pair.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=389040Documentos Relacionados
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