The Influence of the Carbonic Anhydrase Inhibitor, Benzolamide (CL-11,366), on the Reabsorption of Chloride, Sodium, and Bicarbonate in the Proximal Tubule of the Rat
AUTOR(ES)
Kunau, Robert T.
RESUMO
Benzolamide (CL-11,366), a potent carbonic anhydrase inhibitor, was used to examine the influence of carbonic anhydrase inhibition on the reabsorption of chloride, sodium, and bicarbonate in the rat proximal convoluted tubule. Administration of 2 mg/kg benzolamide was associated with a decrease in the tubular fluid/plasma (TF/P) chloride ratio from 1.19±0.10 (SEM) to 1.06±0.01, and an increase in the TF/P bicarbonate ratio from 0.181±0.02 to 0.584±0.02. This dose of benzolamide significantly reduced proximal fractional reabsorption of chloride by 29.14%, of sodium by 34.3%, and of bicarbonate by 35.64%. These results indicate that benzolamide administration inhibits the reabsorption of all three electrolytes in the proximal convoluted tubule. Although 20 mg/kg benzolamide accentuated the changes in fractional reabsorption, the differences between 2 and 20 mg/kg were not statistically significant.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=302127Documentos Relacionados
- Interrelationships of chloride, bicarbonate, sodium, and hydrogen transport in the human ileum
- Effect of carbonic anhydrase inhibition on superficial and deep nephron bicarbonate reabsorption in the rat.
- Internephron heterogeneity for carbonic anhydrase-independent bicarbonate reabsorption in the rat.
- Renal bicarbonate reabsorption in the rat. I. Effects of hypokalemia and carbonic anhydrase.
- Transport of sodium, chloride, and taurocholate by cultured rat hepatocytes
