The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World

AUTOR(ES)

Lucas, Marianne

FONTE

BioMed Central

RESUMO

West Nile virus (WNV) recently became a major public health concern in North America, the Middle East, and Europe. In contrast with the investigations of the North-American isolates, the neurovirulence properties of Middle-Eastern strains of WNV have not been extensively characterized. Israeli WNV strain IS-98-ST1 that has been isolated from a white stork in 1998, was found to be highly neuroinvasive in adult C57BL/6 mice. Strain IS-98-ST1 infects primary neuronal cells from mouse cortex, causing neuronal death. These results demonstrate that Israeli strain IS-98-ST1 provides a suitable viral model for WNV-induced disease associated with recent WNV outbreaks in the Old World.

Documentos Relacionados

• Serological detection of St. Louis encephalitis virus and West Nile virus in equines from Santa Fe, Argentina
• Seroconversion for west Nile and St. Louis encephalitis viruses among sentinel horses in Colombia
• West Nile encephalitis
• Evaluation of a Diagnostic Algorithm Using Immunoglobulin M Enzyme-Linked Immunosorbent Assay To Differentiate Human West Nile Virus and St. Louis Encephalitis Virus Infections during the 2002 West Nile Virus Epidemic in the United States
• Nucleic Acid Sequence-Based Amplification Assays for Rapid Detection of West Nile and St. Louis Encephalitis Viruses