The MexR Repressor of the mexAB-oprM Multidrug Efflux Operon in Pseudomonas aeruginosa: Characterization of Mutations Compromising Activity
AUTOR(ES)
Adewoye, Lateef
FONTE
American Society for Microbiology
RESUMO
Mutations in mexR yield a multidrug resistance phenotype in nalB mutants of Pseudomonas aeruginosa as a result of derepression of the mexAB-oprM multidrug efflux operon. MexR produced by several nalB strains carried single amino acid changes that compromised MexR stability or its ability to dimerize. Changes at residues L95 and R21, however, produced a stable MexR protein capable of dimerization and, thus, likely compromised DNA binding.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=135222Documentos Relacionados
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