The mtp40 gene is not present in all strains of Mycobacterium tuberculosis.
AUTOR(ES)
Weil, A
RESUMO
A multiple PCR-based assay that targets IS6110 and the mtp40 gene was evaluated for the rapid differentiation of Mycobacterium bovis and M. tuberculosis, two of the causative agents of tuberculosis. The IS6110 target is present in both species, whereas the mtp40 gene was thought to be specific for M.tuberculosis (P.Del Portillo, L.A. Murillo, and M.E. Patarroyo, J. Clin. Microbiol. 29:2163-2168, 1991). However, the mtp-40 gene is not present in all M. tuberculosis strains and, hence, is not useful for differentiating M.tuberculosis and M.bovis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=229241Documentos Relacionados
- Specific detection of Mycobacterium tuberculosis by mtp40 nested PCR.
- Evaluation of mtp40 genomic fragment amplification for specific detection of Mycobacterium tuberculosis in clinical specimens.
- Limitações do uso do fragmento mtp40 como marcador de diferenciação entre Mycobacterium tuberculosis e M. bovis
- Identification of B- and T-cell epitopes within the MTP40 protein of Mycobacterium tuberculosis and their correlation with the disease course.
- Pyrazinamide is not effective against intracellularly growing Mycobacterium tuberculosis.
