THE PATHOGENESIS OF AUTOIMMUNITY IN NEW ZEALAND MICE, I. INDUCTION OF ANTINUCLEIC ACID ANTIBODIES BY POLYINOSINIC·POLYCYTIDYLIC ACID
AUTOR(ES)
Steinberg, Alfred D.
RESUMO
Antibodies to DNA and RNA were induced in young NZB/NZW F1 (B/W) female mice following multiple injections of the interferon-inducer polyinosinic·polycytidylic acid (poly I·poly C). Despite serum concentrations of interferon adequate to inhibit the C-type murine leukemia viruses, there was an acceleration of the autoimmune disease in these animals. Anti-RNA, but not anti-DNA antibodies, were induced in B/W male mice, as well as in NZB and NZW mice. Anti-RNA antibodies were also found in 50 per cent of female B/W mice who had never received poly I·poly C and in 8 of 24 sera from patients with systemic lupus erythematosus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=223434Documentos Relacionados
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