The proteasome regulates the UV-induced activation of the AP-1-like transcription factor Gcn4
AUTOR(ES)
Stitzel, Michael L.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
The proteasome is well known for its regulation of the cell cycle and degradation of mis-folded proteins, yet many of its functions are still unknown. We show that RPN11, a gene encoding a subunit of the regulatory cap of the proteasome, is required for UV-stimulated activation of Gcn4p target genes, but is dispensable for their activation by the general control pathway. We provide evidence that RPN11 functions downstream of RAS2, and show that mutation of two additional proteasome subunits results in identical phenotypes. Our analysis defines a novel function of the proteasome: regulation of the RAS- and AP-1 transcription factor-dependent UV resistance pathway.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=312615Documentos Relacionados
- UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.
- UV-induced transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and UV-induced secretion of an extracellular factor that induces HIV-1 transcription in nonirradiated cells.
- UV-induced mutation in bacteriophage T4.
- The UV-induced triplet state in DNA.
- UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.