The RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast.

AUTOR(ES)

Malone, R E

RESUMO

The rad52-1 mutation prevents homothallic mating type interconversion and reduces mitotic recombination in yeast. It has been previously reported that rad52-1 abolishes meiotic recombination. These data suggest either that a generalized recombination function(s) is required for mating type switching or that generalized recombination and specific homothallic functions are jointly controlled by the RAD52 gene. The rad52-1 mutation affects the interconversion of the two yeast mating types (a and alpha) differently, suggesting that the interconversion process is not equivalent for both mating types. This type of asymmetry is not predicted by current models of homothallic switching.

Documentos Relacionados

• The role of recombination and RAD52 in mutation of chromosomal DNA transformed into yeast.
• Homothallic mating type switching generates lethal chromosome breaks in rad52 strains of Saccharomyces cerevisiae.
• Effects of the RAD52 Gene on Recombination in SACCHAROMYCES CEREVISIAE
• Interconversion of Yeast Mating Types II. Restoration of Mating Ability to Sterile Mutants in Homothallic and Heterothallic Strains
• The Genetic Control of Direct-Repeat Recombination in Saccharomyces: The Effect of Rad52 and Rad1 on Mitotic Recombination at Gal10, a Transcriptionally Regulated Gene