The Role of the Liver in Glucagon Metabolism

AUTOR(ES)

Jaspan, Jonathan B.

RESUMO

Total plasma immunoreactive pancreatic glucagon (IRG) was measured in samples taken simultaneously from the proximal portal vein and superior vena cava of 26 healthy rats. The portal-peripheral ratio of IRG was 2.80±0.25, the portal-peripheral difference (Δ) 124±15 pg/ml, and percentage extraction 58±3. Gel filtration of paired portal and peripheral vein samples showed that reduction in the 3,500-dalton IRG component (glucagon) in peripheral samples accounted for almost all the differences, there being minimal and inconsistent changes in the high molecular weight (>40,000) fraction. The portal-peripheral ratio of the 3,500-dalton glucagon was 5.24±1.10, the portal-peripheral difference 130±33 pg/ml, and the percentage extraction 81±5.

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